Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage.

Abstract

To explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (MMP-9) after intracerebral hemorrhage (ICH) in rats. A rat model of ICH was established by intracerebral injection of collagenase. The brain water content was determined by the wet/dry weight ratio, ultrastructural changes in brain tissue were observed by electron microscopy, and the level of plasma MMP-9 was quantified by ELISA. Atorvastatin showed significant effects in reducing the brain water content, blocking neuron apoptosis, and decreasing plasma MMP-9 in rats with ICH. There was a positive linear correlation between plasma MMP-9 and the brain water content. Atorvastatin can significantly relieve brain edema, decrease the brain injury caused by MMP-9 and protect neurons in rats with ICH.

• Authors: Jing-Jing Cui, Dong Wang, Fei Gao, Yue-Rong Li
• Journal: Cell biochemistry and biophysics (Cell Biochem Biophys) Vol. 62 Issue 1 Pg. 87-90 (Jan 2012) ISSN: 1559-0283 [Electronic] United States
• PMID: 22006254 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Heptanoic Acids
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Neuroprotective Agents
• Pyrroles
• Water
• Atorvastatin
• Matrix Metalloproteinase 9

Topics

• Animals
• Atorvastatin
• Brain (drug effects, pathology)
• Brain Edema (drug therapy, metabolism, pathology)
• Cerebral Hemorrhage (drug therapy, metabolism)
• Disease Models, Animal
• Heptanoic Acids (pharmacology, therapeutic use)
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Male
• Matrix Metalloproteinase 9 (blood)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Pyrroles (pharmacology, therapeutic use)
• Rats
• Rats, Wistar
• Water (metabolism)