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Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta.

Abstract
Neural tube defects (NTDs) are complex congenital malformations resulting from incomplete neurulation in embryo. Despite surgical repair of the defect, most of the patients who survive with NTDs have a multiple system handicap due to neuron deficiency of the defective spinal cord. In this study, we successfully devised a prenatal surgical approach and transplanted mesenchymal stem cells (MSCs) to foetal rat spinal column to treat retinoic acid induced NTDs in rat. Transplanted MSCs survived, grew and expressed markers of neurons, glia and myoblasts in the defective spinal cord. MSCs expressed and perhaps induced the surrounding spinal tissue to express neurotrophic factors. In addition, MSC reduced spinal tissue apoptosis in NTD. Our results suggested that prenatal MSC transplantation could treat spinal neuron deficiency in NTDs by the regeneration of neurons and reduced spinal neuron death in the defective spinal cord.
AuthorsHui Li, Fei Gao, Lili Ma, Junhong Jiang, Jianing Miao, Mingyu Jiang, Yang Fan, Lili Wang, Di Wu, Bo Liu, Weilin Wang, Vincent Chi Hang Lui, Zhengwei Yuan
JournalJournal of cellular and molecular medicine (J Cell Mol Med) Vol. 16 Issue 7 Pg. 1606-17 (Jul 2012) ISSN: 1582-4934 [Electronic] England
PMID22004004 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
Chemical References
  • Tretinoin
Topics
  • Animals
  • Apoptosis (physiology)
  • Cell Differentiation (physiology)
  • Cells, Cultured
  • Disease Models, Animal
  • Female
  • Fetus (physiopathology, surgery)
  • Fluorescent Antibody Technique
  • In Situ Nick-End Labeling
  • Mesenchymal Stem Cell Transplantation (methods)
  • Mesenchymal Stem Cells (cytology)
  • Microinjections
  • Pregnancy
  • Rats
  • Rats, Wistar
  • Real-Time Polymerase Chain Reaction
  • Spina Bifida Cystica (chemically induced, physiopathology, therapy)
  • Spinal Cord (physiopathology)
  • Tretinoin (toxicity)

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