Abstract | BACKGROUND: METHODS: Male SHRSP rats, were fed a defatted control diet containing 10% wt/wt soybean oil or a defatted treatment diet containing 10% wt/wt canola oil, and given tap water or water containing 1% NaCl. Blood was collected at the end of study for analysis of red blood cell (RBC) antioxidant enzymes, RBC and plasma malondialdehyde (MDA), plasma 8-isoprostane and plasma lipids. The aorta was removed and the mRNA expression of NOX2, p22phox, CuZn-SOD, Mn-SOD and EC-SOD were determined. RESULTS: CONCLUSION: In conclusion, these results indicate that canola oil reduces antioxidant status and increases plasma lipids, which are risk factors for cardiovascular disease. However, canola oil in combination with salt intake increased MDA, a marker of lipid peroxidation and decreased NAPDH oxidase subunits and aortic SOD gene expression.
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Authors | Annateresa Papazzo, Xavier Conlan, Louise Lexis, Paul Lewandowski |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 10
Pg. 180
(Oct 17 2011)
ISSN: 1476-511X [Electronic] England |
PMID | 21999921
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Fatty Acids, Monounsaturated
- Isoenzymes
- RNA, Messenger
- Rapeseed Oil
- 8-epi-prostaglandin F2alpha
- Dinoprost
- Oxidoreductases
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Topics |
- Animals
- Aorta
(enzymology, metabolism)
- Biomarkers
(blood)
- Diet, Sodium-Restricted
- Dinoprost
(analogs & derivatives, blood)
- Erythrocytes
(enzymology, metabolism)
- Fatty Acids, Monounsaturated
(adverse effects, therapeutic use)
- Gene Expression Regulation, Enzymologic
- Hypercholesterolemia
(etiology, prevention & control)
- Hypertension
(blood, diet therapy, physiopathology)
- Isoenzymes
(blood, genetics, metabolism)
- Lipid Peroxidation
- Male
- Oxidative Stress
- Oxidoreductases
(blood, genetics, metabolism)
- RNA, Messenger
(metabolism)
- Random Allocation
- Rapeseed Oil
- Rats
- Rats, Inbred SHR
- Risk Factors
- Stroke
(etiology, prevention & control)
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