Abstract | BACKGROUND: METHODOLOGY: A total of 65,723 women (20-79 years of age) without cancer or the use of Chinese herbal products were recruited from a nation-wide one-million representative sample of the National Health Insurance of Taiwan and followed from 1997 to 2008. Seven hundred and eighty incidents of invasive breast cancer were diagnosed. Using a reference group that comprised 40,052 women who had never received a hormone prescription, Cox proportional hazard models were constructed to determine the hazard ratios for receiving different types of HT and the occurrence of breast cancer. CONCLUSIONS: 5,156 (20%) women ever used E+P, 2,798 (10.8%) ever used E-alone, and 17,717 (69%) ever used other preparation types. The Cox model revealed adjusted hazard ratios (HRs) of 2.05 (95% CI 1.37-3.07) for current users of E-alone and 8.65 (95% CI 5.45-13.70) for current users of E+P. Using women who had ceased to take hormonal medication for 6 years or more as the reference group, the adjusted HRs were significantly elevated and greater than current users and women who had discontinued hormonal medication for less than 6 years. Current users of either E-alone or E+P have an increased risk for invasive breast cancer in Taiwan, and precautions should be taken when such agents are prescribed.
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Authors | Jung-Nien Lai, Chien-Tung Wu, Pau-Chung Chen, Chiun-Sheng Huang, Song-Nan Chow, Jung-Der Wang |
Journal | PloS one
(PLoS One)
Vol. 6
Issue 10
Pg. e25183
( 2011)
ISSN: 1932-6203 [Electronic] United States |
PMID | 21998640
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Breast Neoplasms
(epidemiology, etiology, pathology)
- Cohort Studies
- Female
- Hormone Replacement Therapy
(adverse effects)
- Humans
- Middle Aged
- Multivariate Analysis
- Neoplasm Invasiveness
- Proportional Hazards Models
- Retrospective Studies
- Risk
- Taiwan
(epidemiology)
- Young Adult
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