Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: We studied 27 obese (BMI: 37.2 ± 0.9 kg/m(2)) insulin-dependent patients with type 2 diabetes mellitus (14 men and 13 women, aged 55 ± 2 years) who received a 16-week very low calorie diet (VLCD). At baseline and after a 16-week VLCD, plasma lipids, lipoproteins, and CETP were measured. Furthermore, functionality of HDL with respect to inducing cholesterol efflux from human monocyte cells (THP-1) was determined. RESULTS: A 16-week VLCD markedly decreased plasma CETP concentration (-18%; P < 0.01) and increased plasma apolipoprotein ( apo)AI levels (+16%; P < 0.05), without significantly affecting plasma HDL-cholesterol and HDL- phospholipids. Although a VLCD results in HDL that is less lipidated, the functionality of HDL with respect to inducing cholesterol efflux in vitro was unchanged. CONCLUSIONS: The marked decrease in hepatic TG content induced by a 16-week VLCD is accompanied by a decrease in plasma CETP concentration and an increase in apoAI levels, without improving the cholesterol efflux properties of HDL in vitro.
|
Authors | Yanan Wang, Marieke Snel, Jacqueline T Jonker, Sebastiaan Hammer, Hildo J Lamb, Albert de Roos, A Edo Meinders, Hanno Pijl, Johannes A Romijn, Johannes W A Smit, Ingrid M Jazet, Patrick C N Rensen |
Journal | Diabetes care
(Diabetes Care)
Vol. 34
Issue 12
Pg. 2576-80
(Dec 2011)
ISSN: 1935-5548 [Electronic] United States |
PMID | 21994427
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Apolipoprotein A-I
- CETP protein, human
- Cholesterol Ester Transfer Proteins
- Lipoproteins, HDL
- Triglycerides
- Cholesterol
|
Topics |
- Apolipoprotein A-I
(blood)
- Caloric Restriction
- Cholesterol
(metabolism)
- Cholesterol Ester Transfer Proteins
(blood)
- Diabetes Mellitus, Type 2
(blood, diet therapy)
- Female
- Humans
- Lipoproteins, HDL
(metabolism)
- Male
- Middle Aged
- Obesity
- Triglycerides
(blood)
|