Abstract | AIM: To investigate the efficacy of rebamipide in a rat model of colitis and restitution of intestinal epithelial cells in vitro. METHODS: Acute colitis was induced with trinitrobenzene sulfonic acid (TNBS) in male Wistar rats. Rats received intrarectal rebamipide treatment daily starting on day 7 and were sacrificed on day 14 after TNBS administration. The distal colon was removed to evaluate the various parameters of inflammation. Moreover, wound healing assays were used to determine the enhanced restitution of rat intestinal epithelial (RIE) cells treated with rebamipide. RESULTS: CONCLUSION:
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Authors | Tomohisa Takagi, Yuji Naito, Kazuhiko Uchiyama, Toshimitsu Okuda, Katsura Mizushima, Takahiro Suzuki, Osamu Handa, Takeshi Ishikawa, Nobuaki Yagi, Satoshi Kokura, Hiroshi Ichikawa, Toshikazu Yoshikawa |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 17
Issue 33
Pg. 3802-9
(Sep 07 2011)
ISSN: 2219-2840 [Electronic] United States |
PMID | 21987622
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Ulcer Agents
- Quinolones
- rebamipide
- Alanine
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Topics |
- Alanine
(analogs & derivatives, pharmacology, therapeutic use)
- Animals
- Anti-Ulcer Agents
(pharmacology, therapeutic use)
- Cell Line
- Colon
(anatomy & histology, drug effects, pathology)
- Epithelial Cells
(cytology, drug effects, physiology)
- Intestinal Mucosa
(cytology, drug effects)
- Male
- Quinolones
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Ulcer
(chemically induced, drug therapy, pathology)
- Wound Healing
(drug effects)
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