HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Polyomavirus-infected decoy cells in cytocentrifuged urine cytology specimens from renal transplant recipients.

AbstractOBJECTIVE:
To evaluate the prevalence of BK virus (BKV) infection in renal transplant recipients based on the detection of urinary decoy cells.
METHODS:
Fifty transplantation patients (56% males) aged 39.9 ± 11 years were screened for urinary decoy cells. The majority (86%) had received grafts from living donors. The inclusion criteria were graft dysfunction, hematuria, and/or leukocyturia. Creatinine and urea serum levels were monitored for 6 months.
RESULTS:
Decoy cells were found in the urine of 12 (24%) patients 1-2 years after transplantation. The immunosuppression regimens most frequently adopted by BKV-positive patients were cyclosporine + azathiprine (50%) and FK + mycophenolate mofetyl + prednisone (25%). A renal biopsy revealed normal structures in 7 patients (58.4%), BKV nephropathy with lymphomononuclear infiltrate and fibrosis in 4 patients (33.3%), and acute cellular rejection with lymphomononuclear infiltrate without fibrosis in 1 patient (8.3%). In the latter patient, BKV-associated nephropathy was confirmed by immunohistochemistry. During the first month, creatinine and urea serum levels were higher among patients with urinary decoy cells. Creatinine levels decreased between the first and the sixth months.
CONCLUSION:
The finding of BKV-associated nephropathy in 33.3% of the patients with urinary decoy cells stresses the importance of screening for BKV with urinary cytology.
AuthorsT M C Maia, S F R Silva, S L Silva, M C Holanda, J M Nascimento, M V P Ferreira
JournalActa cytologica (Acta Cytol) Vol. 55 Issue 5 Pg. 445-8 ( 2011) ISSN: 0001-5547 [Print] Switzerland
PMID21986172 (Publication Type: Journal Article)
CopyrightCopyright © 2011 S. Karger AG, Basel.
Chemical References
  • Immunosuppressive Agents
  • Creatinine
Topics
  • Adult
  • BK Virus (pathogenicity)
  • Creatinine (metabolism)
  • Cross-Sectional Studies
  • Cytological Techniques
  • Epithelial Cells (pathology, virology)
  • Female
  • Follow-Up Studies
  • Graft Rejection (urine, virology)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Kidney Transplantation (adverse effects)
  • Male
  • Polyomavirus Infections (diagnosis, urine, virology)
  • Postoperative Complications
  • Tumor Virus Infections (diagnosis, urine, virology)
  • Urine (cytology, virology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: