Abstract | BACKGROUND/AIMS:
Stannous fluoride (SnF) has been suggested as a dental erosion-preventive agent. The aim of this single-centre, randomized, double-blind, in situ study was to evaluate the effect of toothpastes with SnF in the prevention of erosive enamel wear. METHODS: A combined split-mouth (extra-oral water or toothpaste brushing) and crossover (type of toothpaste) set-up was used. Twelve volunteers wore palatal appliances containing human enamel samples. Three toothpastes were used, in three consecutive runs, in randomized order: two toothpastes containing SnF (coded M and PE) and one toothpaste containing only sodium fluoride (coded C). On day 1 of each run the appliances were worn for pellicle formation. On days 2-5 the samples were also brushed twice with a toothpaste-water slurry or only water (control). Erosion took place on days 2-5 extra-orally 3 times a day (5 min) in a citric acid solution (pH 2.3). Enamel wear depth was quantified by optical profilometry. The effect of toothpastes was tested using General Linear Modeling. RESULTS: Average erosive wear depth of control samples was 23 μm. Both SnF toothpastes significantly reduced erosive wear: M by 34% (SD 39%) and PE by 26% (SD 25%). The control toothpaste reduced erosive wear non-significantly by 7% (SD 20%). Both SnF-containing toothpastes significantly reduced erosive wear compared to the sodium fluoride toothpaste. CONCLUSION:
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Authors | M C D N J M Huysmans, D H J Jager, J L Ruben, D E M F Unk, C P A H Klijn, A M Vieira |
Journal | Caries research
(Caries Res)
Vol. 45
Issue 6
Pg. 518-23
( 2011)
ISSN: 1421-976X [Electronic] Switzerland |
PMID | 21985895
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Tin Fluorides
- Toothpastes
- Citric Acid
- Sodium Fluoride
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Topics |
- Adult
- Citric Acid
(pharmacology)
- Cross-Over Studies
- Dental Enamel
(drug effects, pathology, ultrastructure)
- Double-Blind Method
- Female
- Humans
- Linear Models
- Male
- Middle Aged
- Sodium Fluoride
(therapeutic use)
- Statistics, Nonparametric
- Tin Fluorides
(therapeutic use)
- Tooth Erosion
(prevention & control)
- Toothpastes
(chemistry, therapeutic use)
- Young Adult
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