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Reduction of erosive wear in situ by stannous fluoride-containing toothpaste.

AbstractBACKGROUND/AIMS:
Stannous fluoride (SnF) has been suggested as a dental erosion-preventive agent. The aim of this single-centre, randomized, double-blind, in situ study was to evaluate the effect of toothpastes with SnF in the prevention of erosive enamel wear.
METHODS:
A combined split-mouth (extra-oral water or toothpaste brushing) and crossover (type of toothpaste) set-up was used. Twelve volunteers wore palatal appliances containing human enamel samples. Three toothpastes were used, in three consecutive runs, in randomized order: two toothpastes containing SnF (coded M and PE) and one toothpaste containing only sodium fluoride (coded C). On day 1 of each run the appliances were worn for pellicle formation. On days 2-5 the samples were also brushed twice with a toothpaste-water slurry or only water (control). Erosion took place on days 2-5 extra-orally 3 times a day (5 min) in a citric acid solution (pH 2.3). Enamel wear depth was quantified by optical profilometry. The effect of toothpastes was tested using General Linear Modeling.
RESULTS:
Average erosive wear depth of control samples was 23 μm. Both SnF toothpastes significantly reduced erosive wear: M by 34% (SD 39%) and PE by 26% (SD 25%). The control toothpaste reduced erosive wear non-significantly by 7% (SD 20%). Both SnF-containing toothpastes significantly reduced erosive wear compared to the sodium fluoride toothpaste.
CONCLUSION:
We conclude that SnF-containing toothpastes are able to reduce erosive tooth wear in situ.
AuthorsM C D N J M Huysmans, D H J Jager, J L Ruben, D E M F Unk, C P A H Klijn, A M Vieira
JournalCaries research (Caries Res) Vol. 45 Issue 6 Pg. 518-23 ( 2011) ISSN: 1421-976X [Electronic] Switzerland
PMID21985895 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
CopyrightCopyright © 2011 S. Karger AG, Basel.
Chemical References
  • Tin Fluorides
  • Toothpastes
  • Citric Acid
  • Sodium Fluoride
Topics
  • Adult
  • Citric Acid (pharmacology)
  • Cross-Over Studies
  • Dental Enamel (drug effects, pathology, ultrastructure)
  • Double-Blind Method
  • Female
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Sodium Fluoride (therapeutic use)
  • Statistics, Nonparametric
  • Tin Fluorides (therapeutic use)
  • Tooth Erosion (prevention & control)
  • Toothpastes (chemistry, therapeutic use)
  • Young Adult

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