Abstract | BACKGROUND: AIMS: We examined the association between the circulating 25-hydroxyvitamin D(3) [25( OH)D(3)] concentration and colorectal adenoma in asymptomatic average-risk participants undergoing initial screening colonoscopy. METHODS: The study subjects were comprised of 143 cases of colorectal adenomas and 143 age- and gender-matched controls with normal colonoscopy among the 586 asymptomatic average-risk subjects (median age, 58 years; range, 50-73 years) who underwent first screening colonoscopy and measurement of the serum 25( OH)D(3) between December 2009 and April 2010, consistent with winter months of the region. RESULTS: The mean concentration of serum 25( OH)D(3) in the adenoma and control groups was 20.0 ± 11.0 ng/ml and 25.0 ± 20.0 ng/ml, respectively (P = 0.009). Using multivariate analysis, higher levels of 25( OH)D(3) were associated with a statistically significant decreased risk of colorectal adenoma after multivariable adjustment (highest vs. lowest quartile OR 0.38, 95% CI 0.18-0.80, P (trend) = 0.012). The inverse association of circulating 25( OH)D(3) with colorectal adenoma was stronger among the patients with proximal adenoma than that among the patients without proximal adenoma (highest vs. lowest quartile OR 0.29, 95% CI 0.13-0.66, P (trend) = 0.001). CONCLUSIONS: The present study suggests that high levels of circulating vitamin D are associated with a decreased risk of colorectal adenoma, and especially adenoma located in the proximal colon.
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Authors | Sung Noh Hong, Jeong Hwan Kim, Won Hyeok Choe, Sun-Young Lee, Dong Choon Seol, Hee-Won Moon, Mina Hur, Yeo-Min Yun, In Kyung Sung, Hyung Seok Park, Chan Sup Shim |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 57
Issue 3
Pg. 753-63
(Mar 2012)
ISSN: 1573-2568 [Electronic] United States |
PMID | 21984438
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adenoma
(blood, epidemiology, pathology)
- Age Distribution
- Aged
- Calcifediol
(blood)
- Case-Control Studies
- Colon
(pathology)
- Colonoscopy
(statistics & numerical data)
- Colorectal Neoplasms
(blood, epidemiology, pathology)
- Female
- Humans
- Male
- Mass Screening
(statistics & numerical data)
- Middle Aged
- Multivariate Analysis
- Risk Factors
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