[Relationship between follicle stimulating hormone and AZF microdeletion on Y chromosome in patients with azoospermia or severe oligozoospermia].

Abstract

OBJECTIVE:

To investigate the relationship between follicle stimulating hormone (FSH) and AZF microdeletion on Y chromosome.

METHODS:

Fifteen loci of 4 regions of the AZF gene were investigated by multiplex PCR in 100 patients with azoospermia or severe oligozoospermia. The reproductive hormone FSH was detected by access 2 immunoassay system from BECKMAN COULTER. Epidata was set up and analyzed for means. F test of anova was performed.

RESULTS:

The rate of microdeletion was 13% (13 out of 100 patients). The deletion was on AZFa in 1 patient, AZFb+c+d in 4 patients, AZFc+d in 7 patients, AZFd in 1 patient, respectively. The level of FSH (40.8±11.3 U/L) in the AZFb+c+d deletion group was significantly higher than that in the group without Y chromosome deletion (16.7±14.3 U/L) and the other types of deletion (11.8±6.7 U/L) (P<0.01).

CONCLUSION:

The common microdeletion regions were AZFc and AZFd on Y chromosome in azoospermia or severe oligozoospermia. The microdeletion of AZFb+c+d was one of the important causes of the high level of FSH.

• Authors: Xue-qian Wang, Hong-yan Zhang, Qi-wei Qi, Jing Zhao, Li Xu
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 28 Issue 5 Pg. 559-61 (Oct 2011) ISSN: 1003-9406 [Print] China
• PMID: 21983735 (Publication Type: English Abstract, Journal Article)

Chemical References

• Follicle Stimulating Hormone

Topics

• Adult
• Azoospermia (blood, genetics)
• Chromosome Deletion
• Chromosomes, Human, Y (genetics)
• Follicle Stimulating Hormone (blood)
• Genetic Association Studies
• Genetic Loci (genetics)
• Humans
• Male
• Middle Aged
• Oligospermia (blood, genetics)
• Young Adult