Abstract | OBJECTIVE: DESIGN: Parallel, randomized, double-blind, placebo-controlled clinical trial. SETTING: Academic departments, general hospital, and IVF centers. PATIENT(S): One hundred twenty patients with PCOS at high risk for OHSS. INTERVENTION(S): MAIN OUTCOME MEASURE(S): The primary end point of the current clinical trial was the rate of OHSS. Anthropometric and reproductive data were evaluated. RESULT(S): The total OHSS and cancellation rates were significantly reduced in patients treated with metformin. The relative risk for OHSS was of 0.28 (95% confidence interval, 0.11-0.67). With metformin the stimulation length and the total amount of gonadotropins used were significantly increased, whereas the peak E(2) levels were significantly reduced. CONCLUSION(S): In patients with PCOS who are at high risk for OHSS and who have been stimulated with gonadotropins for IVF cycles, metformin reduces the risk of OHSS by modulating the ovarian response to the stimulation. REGISTRATION ID NUMBER FROM CLINICALTRIALS.GOV: NCT01233206.
|
Authors | Stefano Palomba, Angela Falbo, Laura Carrillo, Maria Teresa Villani, Francesco Orio, Tiziana Russo, Annalisa Di Cello, Fulvio Cappiello, Sabina Capasso, Achille Tolino, Annamaria Colao, Pasquale Mastrantonio, Giovanni Battista La Sala, Fulvio Zullo, Ettore Cittadini, METformin in High Responder Italian Group |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 96
Issue 6
Pg. 1384-1390.e4
(Dec 2011)
ISSN: 1556-5653 [Electronic] United States |
PMID | 21982727
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Copyright | Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Gonadotropins
- Hypoglycemic Agents
- Placebos
- Metformin
|
Topics |
- Administration, Oral
- Adult
- Double-Blind Method
- Down-Regulation
(drug effects)
- Drug Administration Schedule
- Female
- Fertilization in Vitro
(methods)
- Gonadotropins
(therapeutic use)
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacology, therapeutic use)
- Metformin
(administration & dosage, pharmacology, therapeutic use)
- Ovarian Hyperstimulation Syndrome
(epidemiology, etiology, prevention & control)
- Ovulation Induction
(methods)
- Placebos
- Polycystic Ovary Syndrome
(complications, drug therapy)
- Pregnancy
- Risk Factors
|