[Ranitidine in stomach ulcer. Controlled clinical trial of a comparison of administration after the evening meal or before bedtime].

Abstract

In a randomized, double-blind comparative trial, 44 patients with gastric ulcer received one dose of ranitidine 300 mg following the evening meal (between 17.30 and 20.00 hours), and a placebo tablet just before retiring for the night (21.30 to 23.00 hours) (R-P group). In the comparative group, 43 patients received the same substances in the reverse order (P-R group). After four weeks' treatment, the endoscopic follow-up examinations revealed a 76% healing rate in the R-P group and a 63% healing rate in the P-R group. After six weeks, cumulative healing rates of 98% and 81%, respectively (p less than 0.05) were obtained, showing a better healing effect after early evening ingestion of ranitidine. The number of symptoms recorded at the start of treatment had, after four weeks of treatment, decreased considerably more following early-evening ingestion of ranitidine than after late-evening ingestion (p = 0.05). The results of this trial suggest that, in the treatment of gastric ulcers, the early-evening administration of ranitidine 300 mg is more effective than other modes of ingestion.

• Authors: H Brinkhoff, C O Köhler, E M Koch
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 108 Issue 17 Pg. 343-6 (Jun 10 1990) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Ranitidin beim Ulcus ventriculi. Kontrollierte klinische Prüfung zum Vergleich der Einnahme nach dem Abendessen oder vor dem Schlafengehen.
• PMID: 2198208 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Ranitidine

Topics

• Adolescent
• Adult
• Aged
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Randomized Controlled Trials as Topic
• Ranitidine (administration & dosage)
• Stomach Ulcer (drug therapy)