Progressive fatal dementia (Creutzfeldt-Jakob disease) in a patient who received homograft tissue for tympanic membrane closure.

Abstract

We report the case history of a 54-year-old man who developed a fatal neurological disorder 4 years after a successful tympanoplasty with homograft pericardium. The final diagnosis of this case was Creutzfeldt-Jakob disease. This infectious spongiform encephalopathy is probably caused by a slow virus that can be transmitted by transplantation materials. The possible accidental transmission of Creutzfeldt-Jacob disease by the use of homograft materials in otologic surgery is discussed.

• Authors: R A Tange, D Troost, M Limburg
• Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 247 Issue 4 Pg. 199-201 ( 1990) ISSN: 0937-4477 [Print] Germany
• PMID: 2198064 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cialit

Topics

• Cerebral Cortex (pathology)
• Cialit
• Creutzfeldt-Jakob Syndrome (pathology, transmission)
• Humans
• Male
• Middle Aged
• Pericardium (transplantation)
• Time Factors
• Tissue Preservation
• Transplantation, Homologous
• Tympanoplasty