Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese.

Abstract

BACKGROUND:

Monoamine oxidases (MAOs) catalyze the metabolism of dopaminergic neurotransmitters. Polymorphisms of isoforms MAOA and MAOB have been implicated in the etiology of mental disorders such as schizophrenia. Association studies detected these polymorphisms in several populations, however the data have not been conclusive to date. Here, we investigated the association of MAOA and MAOB polymorphisms with schizophrenia in a Han Chinese population.

METHODS:

Two functional single nucleotide polymorphisms (SNPs), rs6323 of MAOA and rs1799836 of MAOB, were selected for association analysis in 537 unrelated schizophrenia patients and 536 healthy controls. Single-locus and Haplotype associations were calculated.

RESULTS:

No differences were found in the allelic distribution of rs6323. The G allele of rs1799836 was identified as a risk factor in the development of schizophrenia (P = 0.00001). The risk haplotype rs6323T-rs1799836G was associated with schizophrenia in female patients (P = 0.0002), but the frequency difference was not significant among male groups.

CONCLUSIONS:

Our results suggest that MAOB is a susceptibility gene for schizophrenia. In contrast, no significant associations were observed for the MAOA functional polymorphism with schizophrenia in Han Chinese. These data support further investigation of the role of MAO genes in schizophrenia.

• Authors: Yi-Liang Wei, Cai-Xia Li, Sheng-Bin Li, Yao Liu, Lan Hu
• Journal: Behavioral and brain functions : BBF (Behav Brain Funct) Vol. 7 Pg. 42 (Oct 06 2011) ISSN: 1744-9081 [Electronic] England
• PMID: 21978760 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 Wei et al; licensee BioMed Central Ltd.

Chemical References

• Monoamine Oxidase

Topics

• Adolescent
• Adult
• Aged
• Asian People (genetics)
• Case-Control Studies
• Child
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease (ethnology, genetics)
• Haplotypes
• Humans
• Male
• Matched-Pair Analysis
• Middle Aged
• Monoamine Oxidase (genetics)
• Polymorphism, Single Nucleotide
• Reference Values
• Saliva (metabolism)
• Schizophrenia (blood, ethnology, genetics)
• Young Adult