Pharmacokinetic pilot study of the antiangiogenic activity of standardized platycodi radix.

Abstract

INTRODUCTION:

Platycodi radix is a radish used in food, such as Korean kimchi, and has been shown to cause weight loss in rodents. Platycodin D is considered its active ingredient and has been shown to inhibit lipases. The authors hypothesized that platycodi radix and the platycodin D it contains inhibit angiogenesis; another mechanism for weight loss.

METHODS:

This study tested platycodi radix extract, platycodin D, and an extract of platycodi radix standardized to platycodin D for their ability to inhibit angiogenesis in a human adipose tissue assay. This study treated five healthy volunteers, orally, with platycodi radix extract standardized to 414 mg of platycodin D. Three volunteers were treated under fasting conditions, one volunteer with a 400 kcal meal, and one volunteer treated with a placebo. Blood was drawn over 5 hours to compare serum inhibition of the human adipose tissue angiogenesis.

RESULTS:

Platycodin radix extract, platycodin D, and platycodi radix extract standardized to platycodin D all inhibited angiogenesis. The three volunteers who consumed platycodi radix extract standardized to 414 mg of platycodin D had a 25.76% reduction in angiogenesis from baseline at 60 minutes (P<0.002), and had a statistically significant reduction in angiogenesis from 30 to 240 minutes (P<0.05 to P<0.002). The placebo decreased angiogenesis by 5.6% between 30 and 240 minutes, compared with 17.8% by the extract. The meal delayed absorption by approximately 3.5 hours.

CONCLUSION:

Platycodi radix extract standardized to platycodin D inhibited angiogenesis in human volunteers, and paves the way for a dose-response study and a human clinical obesity trial.

• Authors: Emma M Twiner, Zhijun Liu, Jeffrey Gimble, Ying Yu, Frank Greenway
• Journal: Advances in therapy (Adv Ther) Vol. 28 Issue 10 Pg. 857-65 (Oct 2011) ISSN: 1865-8652 [Electronic] United States
• PMID: 21975926 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Anti-Obesity Agents
• Plant Extracts
• Saponins
• Triterpenes
• platycodin D

Topics

• Adipose Tissue (blood supply)
• Adult
• Angiogenesis Inhibitors (pharmacokinetics, pharmacology)
• Anti-Obesity Agents (pharmacokinetics, pharmacology)
• Campanulaceae
• Dietary Supplements
• Dose-Response Relationship, Drug
• Humans
• Middle Aged
• Obesity (drug therapy)
• Phytotherapy
• Pilot Projects
• Plant Extracts (pharmacokinetics, pharmacology)
• Saponins (pharmacokinetics, pharmacology)
• Triterpenes (pharmacokinetics, pharmacology)