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Long-term efficacy and safety of the small-sized β2-microglobulin adsorption column for dialysis-related amyloidosis.

Abstract
Dialysis-related amyloidosis (DRA) is one of the major complications often seen in long-term dialysis patients, and is one of the factors that decreases quality of life. β2-microglobulin (β2-m) is considered to be a major pathogenic factor in dialysis-related amyloidosis. The Lixelle adsorbent column, with various capacities, has been developed to adsorb β2-m from the circulating blood of patients with dialysis-related amyloidosis. Using a minimum type of β2-m-adsorbing column (Lixelle S-15), we evaluated its therapeutic efficacy and safety in dialysis patients. Seventeen hemodialysis patients with DRA were treated with the S-15 column for one year. Treatment was performed three times a week in this study. During the study period, pinch strength, visual analog scale for joint pain, and activities of daily living were evaluated every three months, and blood sampling was performed every six months. After one year's treatment with the S-15 column, the β2-m level decreased from 29.3±9.6mg/L to 24.7±5.1mg/L (P<0.05), and the high sensitive C-reactive protein level decreased from 2996±4380ng/mL to 1292±1774ng/mL. After one year of S-15 column use, pinch strength increased from 5.9±3.0pounds to 7.2±3.2pounds (P<0.05), and the visual analog scale for joint pain and activities of daily living score also improved. Long-term use of the Lixelle S-15 column is safe and effective for improvement of quality of life in chronic dialysis patients. Improvement of chronic inflammation may be one of the mechanisms through which the beneficial effects of the column is effected.
AuthorsYuichiro Yamamoto, Nobuhito Hirawa, Satoshi Yamaguchi, Nariaki Ogawa, Hideyuki Takeda, Ken Shibuya, Kimiko Kawahara, Hirofumi Kojima, Yasushi Dobashi, Megumi Fujita, Kengo Azusima, Nobuko Miyazaki, Mayumi Kobayashi, Chinatsu Kobayashi, Akira Fujiwara, Jun Yuto, Sanae Saka, Keisuke Yatsu, Yoshiyuki Toya, Gen Yasuda, Toshimasa Ohnishi, Satoshi Umemura
JournalTherapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 15 Issue 5 Pg. 466-74 (Oct 2011) ISSN: 1744-9987 [Electronic] Australia
PMID21974700 (Publication Type: Journal Article)
Copyright© 2011 The Authors. Therapeutic Apheresis and Dialysis © 2011 International Society for Apheresis.
Chemical References
  • beta 2-Microglobulin
  • C-Reactive Protein
Topics
  • Activities of Daily Living
  • Adsorption
  • Amyloidosis (etiology, therapy)
  • Arthralgia (etiology)
  • Blood Component Removal (methods)
  • C-Reactive Protein (metabolism)
  • Equipment Design
  • Female
  • Humans
  • Inflammation (etiology, therapy)
  • Male
  • Middle Aged
  • Pain Measurement
  • Quality of Life
  • Renal Dialysis (adverse effects)
  • Time Factors
  • Treatment Outcome
  • beta 2-Microglobulin (blood)

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