[The protective effects of Aduola Fuzhenglin on the heart injury induced by microwave exposure in rats].

Abstract

OBJECTIVE:

To study the protective effects of AduoLa Fuzhenglin(ADL) on the heart injury induced by microwave exposure in rats.

METHODS:

One hundred forty male Wistar rats were divided randomly into 5 groups: control, microwave radiation, 0.75 g x kg(-1) d(-1) ADL, 1.50 g x kg(-1) d(-1) ADL and 3.00 g x kg(-1) d(-1) ADL pretreatment groups. Rats in three ADL pretreatment groups were administrated by ADL per day for 2w then exposed to 30 mW/cm2 microwaves for 15 min. The left ventricle blood of rats was obtained at 7 d and 14 d after exposure to microwaves, and the blood Ca2+, AST and CK were detected with Coulter automatic biochemical analyzer, then the histological changes and ultrastructure of heart were observed under light and electron microscopes.

RESULTS:

At 7 d and 14 d after exposure to microwaves, the blood Ca2+, AST and CK concentrations significantly increased (P<0.05 or P<0.01) as compared with controls; Heart muscle fibers showed wavilness, endotheliocyte karyopyknosis, anachromasis; The mitochondria swelling and cavitation, intercalary dies blurred in radiation groups. The changes in 0.75 g x kg(-1) d(-1) ADL pretreatment group were similar to the radiation group, but in 1.50 g x kg(-1)d(-1) and 3.00 g x kg(-1) d(-1) ADL pretreatment groups, above indexes of rats significantly reduced as compared with microwaves group (P<0.05); also the blood Ca2+, AST, CK contents were significantly lower than those in microwave group (P<0.05); The heart showed a tendency to improve.

CONCLUSION:

Microwave radiation (30 mW/cm2) can cause the blood Ca2+, AST and CK turbulence, and heart injury in the histology and ultrastructure; ADL at the dosages of 1.50 g x kg(-1) d(-1) and 3.00 g x kg(-1) d(-1) has a protective effects on the heart injury induced by microwave in rats.

• Authors: Jing Zhang, Rui-yun Peng, Jun-hui Ren, Jing Li, Shui-ming Wang, Ya-bing Gao, Qi Dong, Li Zhao, Shu-chen Liu
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 29 Issue 5 Pg. 367-70 (May 2011) ISSN: 1001-9391 [Print] China
• PMID: 21972535 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Drugs, Chinese Herbal
• Aspartate Aminotransferases
• Creatine Kinase
• Calcium

Topics

• Animals
• Aspartate Aminotransferases (blood)
• Calcium (blood)
• Creatine Kinase (blood)
• Drugs, Chinese Herbal (pharmacology)
• Heart (drug effects, radiation effects)
• Male
• Microwaves (adverse effects)
• Mitochondria, Heart (radiation effects, ultrastructure)
• Myocardium (pathology)
• Rats
• Rats, Wistar