Abstract | PURPOSE: METHODS: Twenty-four male Wistar rats were randomly assigned to four groups (n=6), named according to the treatment applied (G1-Saline, G2-Rut-bpy, G3- L-NAME and G4-L-NAME+Rut-bpy). L-NAME (30 mg/Kg) was injected intraperitoneally 30 minutes before the administration of Rut-bpy (100 mg/Kg). Mean abdominal aorta arterial blood pressure (MAP) was continuously monitored. RESULTS: Mean arterial blood pressure (MAP) in G3 rats rose progressively, reaching 147±16 mmHg compared with 100±19 mm Hg in G1 rats (p<0.05). In G4 rats, treated with L-NAME+Rut-bpy, MAP reached 149+11 mm Hg while in G2 rats, treated with Rut-bpy, MAP values were 106±11 mm Hg. In G1 rats these values decreased progressively reaching 87+14 mm Hg after 30 minutes. An important finding was the maintenance of the MAP throughout the experiment in G2 rats. CONCLUSION: Rut-bpy does not decrease the MAP in L-Name induced hypertensive rats. However, when it is used in anesthetized hypotensive rats a stable blood pressure is obtained.
|
Authors | Marcio Wilker Soares Campelo, Ana Paula Bomfim Soares Campelo, Luiz Gonzaga de França Lopes, Armenio Aguiar Dos Santos, Sergio Botelho Guimarães, Paulo Roberto Leitão de Vasconcelos |
Journal | Acta cirurgica brasileira
(Acta Cir Bras)
Vol. 26 Suppl 1
Pg. 57-9
( 2011)
ISSN: 1678-2674 [Electronic] Brazil |
PMID | 21971659
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Coordination Complexes
- Nitric Oxide Donors
- Organometallic Compounds
- Vasodilator Agents
- Nitric Oxide
- Ruthenium
- NG-Nitroarginine Methyl Ester
|
Topics |
- Anesthesia
- Animals
- Blood Pressure
(drug effects, physiology)
- Coordination Complexes
(pharmacology)
- Disease Models, Animal
- Hypertension
(chemically induced, drug therapy, metabolism)
- Male
- NG-Nitroarginine Methyl Ester
- Nitric Oxide
(biosynthesis)
- Nitric Oxide Donors
(pharmacology)
- Organometallic Compounds
(metabolism, pharmacology)
- Random Allocation
- Rats
- Rats, Wistar
- Ruthenium
(metabolism, pharmacology)
- Treatment Outcome
- Vasodilator Agents
(metabolism, pharmacology)
|