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Letter: Neutrophilic eccrine hidroadenitis with atypical findings.

Abstract
Neutrophilic eccrine hidradenitis (NEH) was originally described as a distinctive dermatosis occurring in patients undergoing chemotherapy, especially associated with the use of cytarabine in the treatment of acute myelogenous leukemia (AML). This disorder is characterized by a neutrophilic infiltrate around the eccrine glands and coils and is associated with necrosis. However, atypical findings in the histology have been reported. To the best of our knowledge, leukocytoclastic vasculitis has not been described in association with NEH. We hypothesize that a toxic effect of cytarabine may damage the vessel wall to some extent, causing a vasculitic phenomenon.
AuthorsEmiliano Grillo, Sergio Vano-Galvan, Carmen Gonzalez, Jaén Pedro
JournalDermatology online journal (Dermatol Online J) Vol. 17 Issue 9 Pg. 14 (Sep 15 2011) ISSN: 1087-2108 [Electronic] United States
PMID21971279 (Publication Type: Case Reports, Letter)
Chemical References
  • Cytarabine
Topics
  • Adult
  • Cytarabine (adverse effects)
  • Female
  • Hidradenitis (chemically induced, complications, pathology)
  • Humans
  • Leukemia, Monocytic, Acute (drug therapy)
  • Neutrophils (pathology)
  • Vasculitis, Leukocytoclastic, Cutaneous (complications, pathology)

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