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[A case of meningeal carcinomatosis due to gastric cancer treated with intrathecal chemotherapy].

Abstract
A 71-year-old man was admitted to our hospital in September 2009 because of severe headache due to meningeal carcinomatosis. In July 2007, subtotal gastrectomy was carried out for gastric cancer. Because intraabdominal cytodiagnosis was positive, he received systemic chemotherapy for 2 years. Recurrent signs were not found on chest or abdominal CT just before hospitalization. He was given NSAIDs and corticosteroid, but his symptom did not improve. Subsequent intrathecal chemotherapy with MTX and Ara-C improved clinical symptoms dramatically. He received care at home for 3 months before he passed away due to pleural and peritoneal recurrence. Recently, since the frequency of meningeal carcinomatosis is increasing, combination treatment of intrathecal chemotherapy and systemic chemotherapy should be considered not only for improvement of clinical manifestations, but also for prognostic improvement.
AuthorsYuka Kobayashi, Soichi Sugitani, Koshi Oseki, Takao Iiri
JournalNihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 108 Issue 10 Pg. 1696-704 (Oct 2011) ISSN: 0446-6586 [Print] Japan
PMID21971143 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Antimetabolites, Antineoplastic
  • Cytarabine
  • Methotrexate
Topics
  • Adenocarcinoma (pathology)
  • Aged
  • Antimetabolites, Antineoplastic (administration & dosage)
  • Cytarabine (administration & dosage)
  • Humans
  • Injections, Spinal
  • Male
  • Meningeal Carcinomatosis (drug therapy, secondary)
  • Methotrexate (administration & dosage)
  • Stomach Neoplasms (pathology)

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