Abstract |
A 71-year-old man was admitted to our hospital in September 2009 because of severe headache due to meningeal carcinomatosis. In July 2007, subtotal gastrectomy was carried out for gastric cancer. Because intraabdominal cytodiagnosis was positive, he received systemic chemotherapy for 2 years. Recurrent signs were not found on chest or abdominal CT just before hospitalization. He was given NSAIDs and corticosteroid, but his symptom did not improve. Subsequent intrathecal chemotherapy with MTX and Ara-C improved clinical symptoms dramatically. He received care at home for 3 months before he passed away due to pleural and peritoneal recurrence. Recently, since the frequency of meningeal carcinomatosis is increasing, combination treatment of intrathecal chemotherapy and systemic chemotherapy should be considered not only for improvement of clinical manifestations, but also for prognostic improvement.
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Authors | Yuka Kobayashi, Soichi Sugitani, Koshi Oseki, Takao Iiri |
Journal | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
(Nihon Shokakibyo Gakkai Zasshi)
Vol. 108
Issue 10
Pg. 1696-704
(Oct 2011)
ISSN: 0446-6586 [Print] Japan |
PMID | 21971143
(Publication Type: Case Reports, English Abstract, Journal Article, Review)
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Chemical References |
- Antimetabolites, Antineoplastic
- Cytarabine
- Methotrexate
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Topics |
- Adenocarcinoma
(pathology)
- Aged
- Antimetabolites, Antineoplastic
(administration & dosage)
- Cytarabine
(administration & dosage)
- Humans
- Injections, Spinal
- Male
- Meningeal Carcinomatosis
(drug therapy, secondary)
- Methotrexate
(administration & dosage)
- Stomach Neoplasms
(pathology)
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