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Zinc monotherapy from time of diagnosis for young pediatric patients with presymptomatic Wilson disease.

Abstract
In 4 young pediatric patients with presymptomatic Wilson disease, we found zinc monotherapy beginning at time of diagnosis to be safe and highly effective for follow-up intervals between 1 and 2 years. Such maintenance therapy with zinc can maintain urinary copper excretion between 1 and 3 μg · kg(-1) · day.
AuthorsTatsuki Mizuochi, Akihiko Kimura, Norikazu Shimizu, Hiroshi Nishiura, Masami Matsushita, Makoto Yoshino
JournalJournal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 53 Issue 4 Pg. 365-7 (Oct 2011) ISSN: 1536-4801 [Electronic] United States
PMID21970993 (Publication Type: Journal Article)
Chemical References
  • Copper
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Zinc
Topics
  • Alanine Transaminase (blood)
  • Aspartate Aminotransferases (blood)
  • Asymptomatic Diseases (therapy)
  • Child
  • Child, Preschool
  • Copper (blood, urine)
  • Female
  • Follow-Up Studies
  • Hepatolenticular Degeneration (diagnosis, drug therapy)
  • Humans
  • Zinc (therapeutic use)

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