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Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia.

Abstract
Cancer cachexia is characterised by a progressive loss of muscle, resulting in functional impairment and shorter survival. Eicosapentaenoic acid, an n-3 polyunsaturated fatty acid found in fish, has been studied for its role as an anti-cachexia therapy. Initial results of eicosapentaenoic supplementation in advanced cancer were promising with improvements in lean body mass (LBM), appetite and quality of life. However, subsequent larger phase III clinical trials reported minimal benefits of supplementation. Recently, several studies have used different study designs, which may provide insight on the effectiveness of eicosapentaenoic in cancer cachexia and also on potential sources of divergent results in previous trials. This review examines the potential benefit of eicosapentaenoic supplementation on LBM and discusses limitations with current studies to identify methods which may aid in progressing the research of future clinical trials.
AuthorsR A Murphy, E Yeung, V C Mazurak, M Mourtzakis
JournalBritish journal of cancer (Br J Cancer) Vol. 105 Issue 10 Pg. 1469-73 (Nov 08 2011) ISSN: 1532-1827 [Electronic] England
PMID21970879 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright2011 Cancer Research UK
Chemical References
  • Eicosapentaenoic Acid
Topics
  • Body Composition
  • Cachexia (physiopathology)
  • Clinical Trials as Topic
  • Eicosapentaenoic Acid (administration & dosage)
  • Humans
  • Neoplasms (physiopathology)

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