[Dapsone for chronic skin lesions in 3 children suffering from Henoch-Schönlein vasculitis].

Abstract

We describe 3 cases of chronic purpuric skin lesions in children suffering from systemic vasculitis: 3 children with Henoch-Schönlein purpura. Dapsone was introduced when skin lesions were recurrent, extensive, and persistent, due to its known ability to act as an anti-IgA and as an anticytotoxic agent against polynuclear neutrophils. Fast and complete but purely suspensive healing of skin lesions was noted. One child developed methemoglobinemia, a known side-effect of dapsone, highlighting the need for adequate prescription and follow-up.

• Authors: N Mazille, D Lipsker, M Fischbach
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 18 Issue 11 Pg. 1201-4 (Nov 2011) ISSN: 1769-664X [Electronic] France
• Vernacular Title: Traitement par la dapsone des formes cutanées chroniques du purpura rhumatoïde : à propos de 3 cas.
• PMID: 21963373 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Chemical References

• Dapsone

Topics

• Adolescent
• Dapsone (therapeutic use)
• Female
• Humans
• IgA Vasculitis (complications)
• Male
• Skin Diseases (drug therapy, etiology)