HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Embolization of parasitized extrahepatic arteries to reestablish intrahepatic arterial supply to tumors before yttrium-90 radioembolization.

AbstractPURPOSE:
To perform embolization of parasitized extrahepatic arteries (EHAs) before radioembolization to reestablish intrahepatic arterial supply to large, peripheral tumors, and to evaluate the technical and clinical outcomes of this intervention.
MATERIALS AND METHODS:
Among 201 patients retrospectively analyzed, embolization of 73 parasitized EHAs in 35 patients was performed. Most embolization procedures were performed during preparatory angiography using large particles and coils. Digital subtraction angiography (DSA), C-arm computed tomography (CT), and technetium-99m macroaggregated albumin ((99m)TcMAA) scintigraphy were used to evaluate the immediate perfusion via intrahepatic collateral channels of target tumor areas previously supplied by parasitized EHAs. Follow-up imaging of differential regional tumor response was used to evaluate microsphere distribution and clinical outcome.
RESULTS:
After embolization, reestablishment of intrahepatic arterial supply was confirmed by both DSA and C-arm CT in 94% of territories and by scintigraphy in 96%. In 32% of patients, the differential response of treatment could not be evaluated because of uniform disease progression. However, symmetric regional tumor response in 94% of evaluable patients indicated successful delivery of microspheres to the territories previously supplied by parasitized EHAs.
CONCLUSIONS:
Reestablishment of intrahepatic arterial inflow to hepatic tumors by embolization of parasitized EHAs is safe and effective and results in successful delivery of yttrium-90 microspheres to tumors previously perfused by parasitized EHAs.
AuthorsMohamed H K Abdelmaksoud, John D Louie, Nishita Kothary, Gloria L Hwang, William T Kuo, Lawrence V Hofmann, David M Hovsepian, Daniel Y Sze
JournalJournal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 22 Issue 10 Pg. 1355-62 (Oct 2011) ISSN: 1535-7732 [Electronic] United States
PMID21961979 (Publication Type: Journal Article)
CopyrightCopyright © 2011 SIR. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Radiopharmaceuticals
  • Technetium Tc 99m Aggregated Albumin
  • Yttrium Radioisotopes
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Angiography, Digital Subtraction
  • California
  • Collateral Circulation
  • Embolization, Therapeutic (adverse effects)
  • Female
  • Hepatic Artery (diagnostic imaging, physiopathology)
  • Humans
  • Liver Circulation
  • Liver Neoplasms (blood supply, diagnosis, radiotherapy)
  • Male
  • Microspheres
  • Middle Aged
  • Perfusion Imaging (methods)
  • Predictive Value of Tests
  • Radiopharmaceuticals (administration & dosage, adverse effects)
  • Retrospective Studies
  • Technetium Tc 99m Aggregated Albumin
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Young Adult
  • Yttrium Radioisotopes (administration & dosage, adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: