Histologic and electron microscopic characterization of the antiperinuclear factor antigen.

Abstract

The presence of the antiperinuclear factor, an autoantibody that recognizes cytoplasmic antigens, was detected in sera from patients with rheumatoid arthritis (59%), seronegative rheumatoid arthritis (36%), systemic lupus erythematosus (46%), systemic sclerosis (26%), and in nonautoimmune controls (10%). The antigenic perinuclear granules were found in the stratum intermedium layer of the buccal mucosa. Granules exhibited histologic features of nucleoproteins, stained for ribonucleoprotein, and showed the ultrastructural characteristics of aggregated rough endoplasmic reticulum. The antiperinuclear factor may recognize a common autoantigen in connective tissue disease.

• Authors: F B Vivino, G G Maul
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 33 Issue 7 Pg. 960-9 (Jul 1990) ISSN: 0004-3591 [Print] United States
• PMID: 2196059 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Autoantibodies
• Rheumatoid Factor

Topics

• Arthritis, Rheumatoid (immunology, pathology)
• Autoantibodies (analysis)
• Cytoplasmic Granules (immunology)
• Endoplasmic Reticulum (ultrastructure)
• Humans
• Immunoenzyme Techniques
• Microscopy, Electron
• Mouth Mucosa (cytology)
• Rheumatoid Factor (immunology)