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Treatment of Paget's disease of bone with aminohydroxybutylidene bisphosphonate.

Abstract
This study examined the effects of aminohydroxybutylidene bisphosphonate in 30 patients with Paget's disease of bone, administered as an intravenous infusion for 5 consecutive days. Treatment (5 mg IV daily) induced marked suppression of biochemical indices of disease activity. Urinary excretion of hydroxyproline fell to 50% of pretreatment values within 2 weeks and was followed by a similar, but later, decline in the serum activity of alkaline phosphatase. Disease activity remained suppressed throughout the 6 months of observation, and only 1 patients showed biochemical signs of an early relapse. Symptomatic improvement was noted in 27 of the 30 patients. Bone biopsies, undertaken in 10 patients, indicated no adverse effects on mineralization. Transient falls were noted in the total white cell count, particularly the lymphocyte and neutrophil fractions, and were associated with short-lived fever in 3 patients. We conclude that short courses of intravenous AHButBP provide a promising treatment for active Paget's disease of bone.
AuthorsD P O'Doherty, D R Bickerstaff, E V McCloskey, N A Hamdy, M N Beneton, S Harris, M Mian, J A Kanis
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (J Bone Miner Res) Vol. 5 Issue 5 Pg. 483-91 (May 1990) ISSN: 0884-0431 [Print] United States
PMID2195845 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Diphosphonates
  • Alendronate
Topics
  • Aged
  • Aged, 80 and over
  • Alendronate
  • Bone Density (drug effects)
  • Bone Resorption (drug therapy)
  • Clinical Trials as Topic
  • Diphosphonates (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Humans
  • Infusions, Intravenous
  • Leukopenia (chemically induced)
  • Male
  • Middle Aged
  • Osteitis Deformans (blood, drug therapy, physiopathology)

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