[Succinate dehydrogenase and cytochrome oxidase activity in rat liver tissue under the influence of valexon].

Abstract

The cytochrome oxidase and succinate dehydrogenase activities were studied in the liver supernatant fraction and homogenate of rats whom different amounts of valexon, organophosphoric pesticide with a hepatotoxic effect, were administered to. A significant increase in the enzymic activity in the supernatant fraction and the resulted rise in the value of the ratio of the activity in the supernatant fraction to that in the homogenate were found five days after a single administration of the preparation in a dose of 310 mg per 1 kg of body weight and after its three-month administration in a dose of 31 mg/kg. These changes may be believed to result from disturbances of the structural-functional state of the mitochondria due to penetration of valexon and its accumulation in them.

• Authors: U A Kuz'minskaia, L M Veremenko
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1978 Nov-Dec Vol. 50 Issue 6 Pg. 711-3 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Suktsinatdegidrogenaznaia i tsitokhromoksidaznaia aktivnosti v tkani Pecheni krys pri deĭstvii valeksona.
• PMID: 219573 (Publication Type: Journal Article)

Chemical References

• Organothiophosphorus Compounds
• phoxim
• Succinate Dehydrogenase
• Electron Transport Complex IV

Topics

• Animals
• Electron Transport Complex IV (metabolism)
• Liver (drug effects, enzymology)
• Male
• Mitochondria, Liver (drug effects)
• Organothiophosphorus Compounds (administration & dosage, pharmacology)
• Rats
• Subcellular Fractions (enzymology)
• Succinate Dehydrogenase (metabolism)