HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Responsive neuromodulators based on artificial neural networks used to control seizure-like events in a computational model of epilepsy.

Abstract
Deep brain stimulation (DBS) has been noted for its potential to suppress epileptic seizures. To date, DBS has achieved mixed results as a therapeutic approach to seizure control. Using a computational model, we demonstrate that high-complexity, biologically-inspired responsive neuromodulation is superior to periodic forms of neuromodulation (responsive and non-responsive) such as those implemented in DBS, as well as neuromodulation using random and random repetitive-interval stimulation. We configured radial basis function (RBF) networks to generate outputs modeling interictal time series recorded from rodent hippocampal slices that were perfused with low Mg²⁺/high K⁺ solution. We then compared the performance of RBF-based interictal modulation, periodic biphasic-pulse modulation, random modulation and random repetitive modulation on a cognitive rhythm generator (CRG) model of spontaneous seizure-like events (SLEs), testing efficacy of SLE control. A statistically significant improvement in SLE mitigation for the RBF interictal modulation case versus the periodic and random cases was observed, suggesting that the use of biologically-inspired neuromodulators may achieve better results for the purpose of electrical control of seizures in a clinical setting.
AuthorsSinisa Colic, Osbert C Zalay, Berj L Bardakjian
JournalInternational journal of neural systems (Int J Neural Syst) Vol. 21 Issue 5 Pg. 367-83 (Oct 2011) ISSN: 1793-6462 [Electronic] Singapore
PMID21956930 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Neurotransmitter Agents
  • Magnesium
  • Potassium
Topics
  • Action Potentials (physiology)
  • Animals
  • Computer Simulation
  • Deep Brain Stimulation
  • Epilepsy (physiopathology)
  • Hippocampus (physiology, physiopathology)
  • Humans
  • Magnesium (metabolism)
  • Male
  • Neural Networks, Computer
  • Neurotransmitter Agents
  • Potassium (metabolism)
  • ROC Curve
  • Rats
  • Rats, Wistar
  • Seizures (physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: