[Pulmonary blastoma. Immunohistochemical characterization of heteromorphic tumor components].

Abstract

The reaction pattern found in thirteen different pulmonary blastomas was tested with four different polyclonal and six different monoclonal antibodies using the avidin-biotin-reaction. Immunohistochemically, the tumours showed positive reactions, both with antibodies that are considered to be epithelial markers (K11, EMA), and with antibodies that indicate a differening mesenchymal differentiation (vimentine, desmine, protein-S100). It was not possible to label any tumour cells with the antibodies anti-beta-HCG, anti-NSE, anti-lysozyme or anti-CEA. The negative response of the CEA reaction can be useful for the differentiation from pulmonary adenocarcinoma, in particular in the case of tumours with highly differentiated glandular components.

• Authors: M Brockmann, A Hecker, K M Müller
• Journal: Pneumologie (Stuttgart, Germany) (Pneumologie) Vol. 44 Suppl 1 Pg. 605-6 (Feb 1990) ISSN: 0934-8387 [Print] Germany
• Vernacular Title: Das pulmonale Blastom. Immunhistochemische Charakterisierung heteromorpher Tumorkomponenten.
• PMID: 2195530 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Biomarkers, Tumor

Topics

• Antibodies, Monoclonal
• Biomarkers, Tumor (analysis)
• Carcinoma, Squamous Cell (pathology)
• Diagnosis, Differential
• Humans
• Immunoenzyme Techniques
• Lung (pathology)
• Lung Neoplasms (pathology)