Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.

Abstract

We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.

• Authors: Xiaoyan Zhou, Martin F Crook, Wanda Sharif-Rodriguez, Yonghua Zhu, Zadok Ruben, Yi Pan, Olga Urosevic-Price, Li Wang, Amy M Flattery, Gail Forrest, Daphne Szeto, Huawei Zhao, Sophie Roy, Michael J Forrest
• Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) (Clin Exp Hypertens) Vol. 33 Issue 8 Pg. 538-47 ( 2011) ISSN: 1525-6006 [Electronic] England
• PMID: 21950654 (Publication Type: Journal Article)

Chemical References

• Electrolytes
• Mineralocorticoid Receptor Antagonists
• Receptors, Mineralocorticoid
• Sodium Chloride, Dietary
• Spironolactone
• Aldosterone
• Eplerenone
• Creatinine

Topics

• Aldosterone (blood)
• Animals
• Blood Pressure (drug effects)
• Chronic Disease
• Creatinine (blood)
• Disease Models, Animal
• Disease Progression
• Electrolytes (blood)
• Eplerenone
• Heart Rate (drug effects)
• Hypertension, Renal (drug therapy, pathology, physiopathology)
• Kidney (drug effects, pathology, physiology)
• Male
• Mineralocorticoid Receptor Antagonists (blood, pharmacology)
• Organ Size
• Rats
• Rats, Inbred Dahl
• Receptors, Mineralocorticoid (physiology)
• Sodium Chloride, Dietary (pharmacology)
• Spironolactone (analogs & derivatives, blood, pharmacology)