[Raltegravir in a special case: patient with HIV and Burkitt's lymphoma].

Abstract

HISTORY AND CLINICAL FINDINGS:

A 38-year-old HIV positive man suffered from right upper abdominal pain and oesophageal reflux syndromes. He was in a good general state of health and nutrition with no concomitant symptoms.

INVESTIGATIONS:

A small bowel tumor and slight soor esophagitis had been diagnosed by esophago-gastroduodenoscopy. The tumor was histologically classified as Burkitt?s lymphoma.

TREATMENT AND OUTCOME:

The patient received 6 cycles of chemotherapy according to the B-ALL protocol, and antiretroviral therapy with lamivudine (300 mg), abacavir (600 mg) und raltegravir (2 × 400 mg) was initiated immediately. After the first cycle of chemotherapy a complete remission of Burkitt?s lymphoma was achieved. Laboratory parameters recovered after completion of 6 cycles to a value of 400 CD4-positive lymphocytes/mm (3) with a viral load of HIV-1-RNA 20 - 300 copies/ml in plasma.

CONCLUSION:

Immediate initiation of antiretroviral therapy is essential after the diagnosis of AIDS-defining symptoms. The choice of an appropriate treatment regimen is a critical factor in order to avoid toxic drug interactions and adverse events while maintaining a highly effective treatment.

• Authors: B Bieniek
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 136 Issue 41 Pg. 2091-3 (Oct 2011) ISSN: 1439-4413 [Electronic] Germany
• Vernacular Title: Raltegravir im Sonderfall - Patient mit HIV und Burkitt-Lymphom.
• PMID: 21948617 (Publication Type: Case Reports, English Abstract, Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Anti-HIV Agents
• Dideoxynucleosides
• Pyrrolidinones
• Lamivudine
• Raltegravir Potassium
• abacavir

Topics

• Adult
• Anti-HIV Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Burkitt Lymphoma (diagnosis, drug therapy)
• CD4 Lymphocyte Count
• Dideoxynucleosides (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Duodenal Neoplasms (diagnosis, drug therapy)
• HIV Seropositivity (diagnosis, drug therapy)
• Humans
• Intestine, Small
• Lamivudine (therapeutic use)
• Lymphoma, AIDS-Related (diagnosis, drug therapy)
• Male
• Pyrrolidinones (adverse effects, therapeutic use)
• Raltegravir Potassium
• Remission Induction
• Viral Load