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[Persistent spontaneous erythema caused by topical use of fumaric acid monoethyl ester--an obligate mast cell degranulation?].

Abstract
In 12 healthy volunteers the topical application of monoethyl fumarate caused a spontaneous persistent erythema. Systemic application induced flush. In urticaria pigmentosa the influence was significant higher than in normal skin. This fact suggests a mast cell degranulation caused by monoethyl fumarate.
AuthorsW Gehring, M Gloor
JournalDermatologische Monatschrift (Dermatol Monatsschr) Vol. 176 Issue 2-3 Pg. 123-8 ( 1990) ISSN: 0011-9083 [Print] Germany
Vernacular TitlePersistierende Spontanerytheme durch topische Anwendung von Fumarsäuremonoethylester--eine obligate Mastzelldegranulation?
PMID2194849 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Fumarates
  • diethyl fumarate
  • ethyl fumarate
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Cell Degranulation (drug effects)
  • Drug Hypersensitivity (etiology)
  • Female
  • Fumarates (administration & dosage, adverse effects)
  • Humans
  • Male
  • Mast Cells (drug effects)
  • Middle Aged
  • Patch Tests
  • Randomized Controlled Trials as Topic
  • Skin Tests

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