Role of Surf1 in heme recruitment for bacterial COX biogenesis.

Abstract

Biogenesis of the mitochondrial cytochrome c oxidase (COX) is a highly complex process involving subunits encoded both in the nuclear and the organellar genome; in addition, a large number of assembly factors participate in this process. The soil bacterium Paracoccus denitrificans is an interesting alternative model for the study of COX biogenesis events because the number of chaperones involved is restricted to an essential set acting in the metal centre formation of oxidase, and the high degree of sequence homology suggests the same basic mechanisms during early COX assembly. Over the last years, studies on the P. denitrificans Surf1 protein shed some light on this important assembly factor as a heme a binding protein associated with Leigh syndrome in humans. Here, we summarise our current knowledge about Surf1 and its role in heme a incorporation events during bacterial COX biogenesis. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes.

• Authors: Achim Hannappel, Freya A Bundschuh, Bernd Ludwig
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1817 Issue 6 Pg. 928-37 (Jun 2012) ISSN: 0006-3002 [Print] Netherlands
• PMID: 21945856 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Bacterial Proteins
• Membrane Proteins
• Mitochondrial Proteins
• Surf-1 protein
• heme a
• Heme
• Electron Transport Complex IV

Topics

• Amino Acid Sequence
• Bacteria (enzymology, genetics)
• Bacterial Proteins (biosynthesis, genetics, physiology)
• Electron Transport Complex IV (biosynthesis)
• Gene Deletion
• Heme (analogs & derivatives, biosynthesis, metabolism)
• Humans
• Membrane Proteins (genetics, physiology)
• Mitochondrial Proteins (genetics, physiology)
• Molecular Sequence Data
• Phenotype
• Protein Binding
• Protein Structure, Tertiary