[Establishment and evaluation of a modified plasma protamine paracoagulation test].

Abstract

OBJECTIVE:

To establish a modified plasma protamine paracoagulation test.

METHODS:

Plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-dimer (D-D) tests were performed for the plasma samples collected from 98 cases of disseminated intravascular coagulation (DIC) and 156 normal subjects. The sensitivity and specificity of the 3 tests were analyzed. The plasma samples from 8 cases of suspected myocardial infarction were detected using modified plasma protamine paracoagulation for diagnostic purpose.

RESULTS:

The sensitivity of plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-D tests was 16.33%, 88.76% and 77.56%, and the specificity was 100%, 88.46% and 97.44%, respectively. Positive results occurred earlier in modified plasma protamine paracoagulation test than in plasma protamine paracoagulation and D-D tests in 5 cases of myocardial infarction.

CONCLUSION:

The modified plasma protamine paracoagulation test has a higher sensitivity than plasma protamine paracoagulation test and a higher specificity than D-D test, and can be helpful in early diagnosis of thrombosis and fibrinolysis.

• Authors: Xu-hua Tang, Qiang Li, Wen-hao Lin, Lin Fu, Qiang Wang, Xiao-ping Xie, Yu-ming Zhang
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 31 Issue 9 Pg. 1626-8 (Sep 2011) ISSN: 1673-4254 [Print] China
• PMID: 21945784 (Publication Type: English Abstract, Journal Article)

Chemical References

• Protamines

Topics

• Adult
• Blood Coagulation Tests (methods)
• Female
• Humans
• Male
• Middle Aged
• Protamines (blood)
• Sensitivity and Specificity
• Thrombosis (blood, diagnosis)