A case with acute disturbance of consciousness associated with
calcium hopanthenate (HOPA) administration was reported. He was a 3-year-old boy with autistic developmental delay, had orally taken 1.5 g of HOPA daily for 3 months. Clinical manifestations consisted of
fever,
vomiting and
coma. Laboratory examination revealed severe
hypoglycemia and
metabolic acidosis, but there were no hepatic
enzyme abnormalities. Analysis of urinary organic
acid profile showed that very large amounts of medium and long chain
dicarboxylic acids and omega-1 hydroxy-
fatty acids were excreted. In particular,
2-hydroxysebacic acid, the accumulation of which has only been reported in the urine of patients with
Zellweger syndrome and
neonatal adrenoleukodystrophy (NALD), was observed. Analysis of urinary acylcarnitines showed that
acetylcarnitine was predominant and C6-C10 dicarboxylic acylcarnitines were also excreted. He was treated with and rapidly responded to intravenous
glucose and
bicarbonate. After withdrawal of the
drug he has had no problems and dicarboxylic aciduria disappeared. A CT scan showed symmetric, low density areas in periventricular white matter, especially around the posterior horns of the lateral ventricles. A T2-weighted MRI scan revealed high-intensity signal in the white matter corresponding to areas of low density on CT scan. We conclude that that a large amount of HOPA administration may cause
encephalopathy by the inhibition of both mitochondrial and peroxisomal beta-oxidation.