Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI.

In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated.
In a prospective, double blinded, placebo controlled, cross-over randomized study the sensations of 34 volunteers before, during and after exposure to the static magnetic field with and without drug respectively placebo administration were quantified. Fast table motion was applied to increase the incidence of otherwise sparse reports of field related sensations.
The strength of vertigo can be reduced by the application of diphenhydramine.
Diphenhydramine, even at a low dose, reduces the strength of vertigo at ultra-high static magnetic fields, may be used preventively, and could pave the way to even higher field strength.
AuthorsMarkus Thormann, Holger Amthauer, Daniela Adolf, Astrid Wollrab, Jens Ricke, Oliver Speck
JournalEuropean journal of radiology (Eur J Radiol) Vol. 82 Issue 5 Pg. 768-72 (May 2013) ISSN: 1872-7727 [Electronic] Ireland
PMID21945402 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Hypnotics and Sedatives
  • Diphenhydramine
  • Adult
  • Diphenhydramine (administration & dosage)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives (therapeutic use)
  • Magnetic Fields (adverse effects)
  • Magnetic Resonance Imaging (adverse effects)
  • Male
  • Middle Aged
  • Nausea (diagnosis, etiology, prevention & control)
  • Placebo Effect
  • Prospective Studies
  • Treatment Outcome
  • Vertigo (diagnosis, etiology, prevention & control)

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