Bioactive constituents from Michelia champaca.

Abstract

(-)-Anonaine (1), (-)-asimilobine (2), (-)-nuciferine (3), (-)-anolobine (4), (-)-romerine (5), (-)-N-acetylanonaine (6), liriodenine (7), (+)-syringaresinol (8), N-trans-feruloyltyramine (9), N-cis-feruloyltyramine (10), scopoletin (11), 4-acetonyl-3,5-dimethoxy-p-quinol (12), vanillin (13), vanillic acid (14), syringic acid (15), beta-sitosterol (16) and stigmasterol (17) were isolated from branches of Michelia champaca L. In addition, a cell proliferation assay of five of the isolated compounds on human breast and lung cancer cells showed that liriodenine (7) was the strongest inhibitor.

• Authors: Yu-Ting Yeh, Jin-Cherng Huang, Po-Lin Kuo, Chung-Yi Chen
• Journal: Natural product communications (Nat Prod Commun) Vol. 6 Issue 9 Pg. 1251-2 (Sep 2011) ISSN: 1934-578X [Print] United States
• PMID: 21941890 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology, therapeutic use)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Female
• Humans
• Lung Neoplasms (drug therapy)
• Magnoliaceae (chemistry)
• Plant Stems (chemistry)