Micronized ferric pyrophosphate supplied through extruded rice kernels improves body iron stores in children: a double-blind, randomized, placebo-controlled midday meal feeding trial in Indian schoolchildren.

Abstract

BACKGROUND:

Micronized ferric pyrophosphate (MFPP) in extruded rice kernels mixed in a rice-based meal could be an effective strategy for improving iron status of children in India.

OBJECTIVE:

The objective was to determine the impact of MFPP supplied through extruded rice kernels in a rice-based meal on iron status of children participating in the midday meal (MDM) scheme in India.

DESIGN:

The sensory characteristics of cooked rice containing MFPP in extruded rice kernels, in vitro availability, and loss of iron during cooking from a typical MDM consisting of 125 g rice (dry weight) containing 19 mg Fe [fortified rice (FR); normal rice mixed with Ultra Rice (extruded kernels containing MFPP of ∼3.14-μm mean particle size)] in comparison with unfortified rice (UFR) were tested. A double-blind, 8-mo, placebo-controlled trial was conducted in 5-11-y-old schoolchildren (n = 140) who were randomly assigned to receive either an FR-MDM or a UFR-MDM. Average consumption amounts of the MDM, height, weight, hemoglobin, ferritin, and C-reactive protein were measured at baseline and at 8 mo.

RESULTS:

The sensory qualities of cooked FR and UFR were similar. The in vitro iron availability from FR-MDM (1.3%) was significantly (P < 0.05) lower than that from UFR-MDM (3.3%). Providing FR-MDM to the schoolchildren for 8 mo improved ferritin significantly (P < 0.001), by 8.2 ± 2.10 μg/L. However, the increase in hemoglobin was similar between groups (FR: 0.99 ± 0.10 g/dL; UFR: 1.15 ± 0.10 g/dL), which suggests that other factors beyond additional iron intake had a large influence on hemoglobin concentration. The prevalence of iron deficiency decreased significantly (P < 0.05) in the FR group (33-14%) and increased marginally in the UFR group (31-37%). The prevalence of anemia and iron deficiency anemia was similar between groups at baseline and at 8 mo.

CONCLUSION:

Regular intake of 19 mg Fe/d in MFPP supplied through extruded rice kernels improves iron stores and reduces iron deficiency among schoolchildren in India.

• Authors: Madhari S Radhika, Krishnapillai M Nair, Rachakulla Hari Kumar, Mendu Vishnuvardhana Rao, Punjal Ravinder, Chitty Gal Reddy, Ginnela N V Brahmam
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 94 Issue 5 Pg. 1202-10 (Nov 2011) ISSN: 1938-3207 [Electronic] United States
• PMID: 21940595 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Diphosphates
• Hemoglobins
• Placebos
• C-Reactive Protein
• Ferritins
• Iron
• ferric pyrophosphate

Topics

• Anemia, Iron-Deficiency (blood, drug therapy)
• C-Reactive Protein (metabolism)
• Child
• Child, Preschool
• Diphosphates (administration & dosage)
• Double-Blind Method
• Female
• Ferritins (blood)
• Food, Fortified
• Hemoglobins (metabolism)
• Humans
• India
• Iron (administration & dosage)
• Male
• Oryza
• Placebos
• Rural Population
• Schools
• Statistics, Nonparametric