Serial changes in cytokine expression in irritable bowel syndrome patients following treatment with calcium polycarbophil.

Abstract

BACKGROUND/AIMS:

Calcium polycarbophil improves abdominal symptoms in patients with irritable bowel syndrome (IBS). We examined cytokine expression in IBS patients before and after administration of calcium polycarbophil.

METHODOLOGY:

A total of 24 IBS patients (13 diarrhea type, 11 constipation type; median age, 55 years) were enrolled. Serum levels of high sensitive C-reactive protein (CRP) and 17 cytokines (interleukin [IL]-1ß, -2, -4, 5, -6, -7, -8, -10, -12, -13 and -17; tumor necrosis factor-a [TNF-a]; interferon [IFN]-?; granulocyte colony-stimulating factor [G-CSF]; granulocyte macrophage colony-stimulating factor [GM-CSF]; macrophage inflammatory protein [MIP]-1ß; and macrophage chemo-attractant protein [MCP-1]) were simultaneously determined using a Bio-Plex suspension array system before and 12 weeks after administration of calcium polycarbophil 1,500-3,000mg/day.

RESULTS:

Serum MCP-1 levels in diarrhea type IBS patients were significantly higher than those in constipation type patients (p<0.05). In IBS patients, no significant changes in serum cytokine levels were observed following calcium polycarbophil administration. In constipation type patients, serum high sensitive CRP levels were significantly lower after treatment than before treatment.

CONCLUSIONS:

Decreases in serum high sensitive CRP levels following calcium polycarbophil treatment may be involved in the relief of abdominal symptoms in IBS patients; diarrhea type IBS is characterized by increased MCP-1 expression.

• Authors: Toshimi Chiba, Kunihiko Sato, Yosuke Toya, Kei Endo, Yukito Abiko, Satoshi Kasugai, Shinji Saito, Shuhei Oana, Norihiko Kudara, Masaki Endo, Kazuyuki Suzuki
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2011 Sep-Oct Vol. 58 Issue 110-111 Pg. 1527-30 ISSN: 0172-6390 [Print] Greece
• PMID: 21940313 (Publication Type: Journal Article)

Chemical References

• Acrylic Resins
• Antidiarrheals
• Cathartics
• Chemokine CCL2
• Cytokines
• calcium polycarbophil
• C-Reactive Protein

Topics

• Acrylic Resins (therapeutic use)
• Adult
• Aged
• Analysis of Variance
• Antidiarrheals (therapeutic use)
• C-Reactive Protein (metabolism)
• Cathartics (therapeutic use)
• Chemokine CCL2 (blood)
• Cytokines (blood)
• Female
• Humans
• Irritable Bowel Syndrome (blood, drug therapy)
• Male
• Middle Aged