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Inhibin beta B: a useful tumor marker in uterine endometrioid adenocarcinomas?

Abstract
Inhibins, dimeric peptide hormones composed of an alpha-subunit and one of two possible beta-subunits (betaA or betaB), exhibit substantial roles in human reproduction and in endocrine-responsive tumours. However, the prognostic significance and clinical implications of the inhibin-betaB subunit in uterine endometrioid adenocarcinomas is still not defined yet. A series of 227 uterine endometrioid adenocarcinomas of a previous well-characterized cohort were re-evaluated for the expression of the inhibin-betaB subunit and correlated with several clinicopathological characteristics and the clinical outcome. In this re-analysis, the betaB-subunit expression demonstrated a significant association with the patients' age and cervical involvement. However, inhibin-betaB did not significantly affect the patients survival in this large cohort group. However, patients with a higher intensity of betaB-subunit immunolabelling had a slightly worse survival expectation, although without any significant association, suggesting that this subunit might have a substantial role in the carcinogenesis and pathology of endometrioid adenocarcinomas. Thus, the inhibin-betaB subunit appears not to be a useful prognostic marker regarding endometrioid adenocarcinomas. However, further research is warranted in elucidating the possible implications of inhibin-βB and endometrial carcinogenesis.
AuthorsI Mylonas
JournalHistology and histopathology (Histol Histopathol) Vol. 26 Issue 11 Pg. 1415-22 (Nov 2011) ISSN: 1699-5848 [Electronic] Spain
PMID21938679 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • INHBB protein, human
  • Inhibin-beta Subunits
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (analysis)
  • Carcinoma, Endometrioid (metabolism, pathology)
  • Endometrial Neoplasms (metabolism, pathology)
  • Female
  • Humans
  • Immunohistochemistry
  • Inhibin-beta Subunits (analysis, biosynthesis)
  • Kaplan-Meier Estimate
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Prognosis

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