Comparison of ceftriaxone (1 x 1 g/day) versus cefotaxime (3 x 1 g/day) for gynecologic and obstetric infections. A randomized clinical trial.

Abstract

A prospective, randomized clinical trial was conducted to compare the efficacy and tolerance of a single dose of 1 g ceftriaxone i.v. daily with 3 doses of 1 g cefotaxime i.v. daily for obstetric and gynecologic infections. Both agents are characterized by a wide spectrum and potent activity. Furthermore, ceftriaxone has an outstanding serum half-life of 8 h. 41 patients with pelvic inflammatory disease, pelvic or wound infections after vaginal or abdominal hysterectomy, endomyometritis and urinary-tract infection were included. Patients were monitored clinically by routine laboratory methods (erythrocyte sedimentation rate, white blood cell count and cross-reacting protein) and bacteriologically. Clinical parameters of infection were fever, local pain and/or tenderness, a sactosalpinx or pyosalpinx at palpation and cervical secretion. Clinical cure was achieved in 77.3% in the ceftriaxone and in 78.9% in the cefotaxime group, improvement in 3 (13.6%) and 4 patients (21.0%), respectively. 2 clinical failures were seen in the ceftriaxone group. One was a severe pelvic infection following vaginal hysterectomy, which responded to the addition of metronidazole, the other was due to a chlamydial salpingitis, which was cured with a 10-day course of doxycycline. Both antibiotics were well tolerated. Our results suggest that for obstetric and gynecologic infections a single 1-gram dose of ceftriaxone is equally effective as three 1-gram doses of cefotaxime.

• Authors: G J Gerstner
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 29 Issue 4 Pg. 273-7 ( 1990) ISSN: 0378-7346 [Print] Switzerland
• PMID: 2193856 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Ceftriaxone
• Cefotaxime

Topics

• Cefotaxime (administration & dosage, therapeutic use)
• Ceftriaxone (administration & dosage, therapeutic use)
• Endometritis (drug therapy)
• Escherichia coli Infections (drug therapy)
• Female
• Humans
• Hysterectomy
• Pelvic Inflammatory Disease (drug therapy)
• Prospective Studies
• Randomized Controlled Trials as Topic
• Surgical Wound Infection (drug therapy)