Abstract |
The purpose of this research was to develop formulation of docetaxel-loaded biodegradable TPGS-b-(PCL-ran- PGA) nanoparticles for breast cancer chemotherapy. A novel diblock copolymer, d-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε- caprolactone-ran-glycolide) [ TPGS-b-(PCL-ran- PGA)], was synthesized from ε- caprolactone, glycolide and d-α-tocopheryl polyethylene glycol 1000 succinate by ring-opening polymerization using stannous octoate as catalyst. The obtained copolymers were characterized by (1)H NMR, GPC and TGA. The docetaxel-loaded TPGS-b-(PCL-ran- PGA) nanoparticles were prepared and characterized. The data showed that the fluorescence TPGS-b-(PCL-ran- PGA) nanoparticles could be internalized by MCF-7 cells. The TPGS-b-(PCL-ran- PGA) nanoparticles achieved significantly higher level of cytotoxicity than commercial Taxotere®. MCF-7 xenograft tumor model on SCID mice showed that docetaxel formulated in the TPGS-b-(PCL-ran- PGA) nanoparticles could effectively inhibit the growth of tumor over a longer period of time than Taxotere® at the same dose. In conclusion, the TPGS-b-(PCL-ran- PGA) copolymer could be acted as a novel and potential biologically active polymeric material for nanoformulation in breast cancer chemotherapy.
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Authors | Laiqiang Huang, Hongbo Chen, Yi Zheng, Xiaosong Song, Ranyi Liu, Kexin Liu, Xiaowei Zeng, Lin Mei |
Journal | Integrative biology : quantitative biosciences from nano to macro
(Integr Biol (Camb))
Vol. 3
Issue 10
Pg. 993-1002
(Oct 2011)
ISSN: 1757-9708 [Electronic] England |
PMID | 21938302
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | This journal is © The Royal Society of Chemistry 2011 |
Chemical References |
- Antineoplastic Agents
- Polyesters
- Taxoids
- Vitamin E
- Docetaxel
- polycaprolactone
- Polyglycolic Acid
- Polyethylene Glycols
- tocophersolan
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, chemistry)
- Breast Neoplasms
(drug therapy)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Docetaxel
- Female
- Humans
- Magnetic Resonance Spectroscopy
- Mice
- Mice, SCID
- Microscopy, Electron, Scanning
- Nanoparticles
(chemistry, therapeutic use, ultrastructure)
- Polyesters
(administration & dosage, chemistry)
- Polyethylene Glycols
(chemistry)
- Polyglycolic Acid
(chemistry)
- Random Allocation
- Taxoids
(administration & dosage, chemistry)
- Vitamin E
(analogs & derivatives, chemistry)
- Xenograft Model Antitumor Assays
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