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Nanoformulation of D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for breast cancer therapy.

Abstract
The purpose of this research was to develop formulation of docetaxel-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles for breast cancer chemotherapy. A novel diblock copolymer, d-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) [TPGS-b-(PCL-ran-PGA)], was synthesized from ε-caprolactone, glycolide and d-α-tocopheryl polyethylene glycol 1000 succinate by ring-opening polymerization using stannous octoate as catalyst. The obtained copolymers were characterized by (1)H NMR, GPC and TGA. The docetaxel-loaded TPGS-b-(PCL-ran-PGA) nanoparticles were prepared and characterized. The data showed that the fluorescence TPGS-b-(PCL-ran-PGA) nanoparticles could be internalized by MCF-7 cells. The TPGS-b-(PCL-ran-PGA) nanoparticles achieved significantly higher level of cytotoxicity than commercial Taxotere®. MCF-7 xenograft tumor model on SCID mice showed that docetaxel formulated in the TPGS-b-(PCL-ran-PGA) nanoparticles could effectively inhibit the growth of tumor over a longer period of time than Taxotere® at the same dose. In conclusion, the TPGS-b-(PCL-ran-PGA) copolymer could be acted as a novel and potential biologically active polymeric material for nanoformulation in breast cancer chemotherapy.
AuthorsLaiqiang Huang, Hongbo Chen, Yi Zheng, Xiaosong Song, Ranyi Liu, Kexin Liu, Xiaowei Zeng, Lin Mei
JournalIntegrative biology : quantitative biosciences from nano to macro (Integr Biol (Camb)) Vol. 3 Issue 10 Pg. 993-1002 (Oct 2011) ISSN: 1757-9708 [Electronic] England
PMID21938302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightThis journal is © The Royal Society of Chemistry 2011
Chemical References
  • Antineoplastic Agents
  • Polyesters
  • Taxoids
  • Vitamin E
  • Docetaxel
  • polycaprolactone
  • Polyglycolic Acid
  • Polyethylene Glycols
  • tocophersolan
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, chemistry)
  • Breast Neoplasms (drug therapy)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Docetaxel
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, SCID
  • Microscopy, Electron, Scanning
  • Nanoparticles (chemistry, therapeutic use, ultrastructure)
  • Polyesters (administration & dosage, chemistry)
  • Polyethylene Glycols (chemistry)
  • Polyglycolic Acid (chemistry)
  • Random Allocation
  • Taxoids (administration & dosage, chemistry)
  • Vitamin E (analogs & derivatives, chemistry)
  • Xenograft Model Antitumor Assays

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