Studies on the electrolytes and microelements in Wistar rat following multiple exposures to acetamiprid.

Abstract

A subacute toxicity study of acetamiprid was undertaken in 72 female Wistar rats randomly divided into four groups (18 each). Acetamiprid was administered orally at the dose rate of 0, 25, 100 and 200 mg/kg of body weight to rats of groups I, II, III and IV, respectively. Group I served as control. Calcium, phosphorous, sodium, potassium, chloride, zinc, copper, iron and cobalt concentrations in plasma were significantly (p ≤ 0.05) increased in acetamiprid administered groups. However, no alteration was observed in plasma manganese concentration in acetamiprid-treated rats. The repeated oral toxicity study on acetamiprid in present investigation suggested that it has toxic potential and it is a high-risk insecticide.

• Authors: Samiran Mondal, Ratan Chandra Ghosh, Sunit Kumar Mukhopadhyaya
• Journal: Toxicology and industrial health (Toxicol Ind Health) Vol. 28 Issue 5 Pg. 422-7 (Jun 2012) ISSN: 1477-0393 [Electronic] England
• PMID: 21937532 (Publication Type: Journal Article)

Chemical References

• Chlorides
• Electrolytes
• Insecticides
• Metals
• Neonicotinoids
• Pyridines
• Phosphorus
• Manganese
• acetamiprid

Topics

• Administration, Oral
• Animals
• Chlorides (blood)
• Electrolytes (blood)
• Female
• Insecticides (toxicity)
• Manganese (blood)
• Metals (blood)
• Neonicotinoids
• Phosphorus (blood)
• Pyridines (toxicity)
• Rats
• Rats, Wistar
• Toxicity Tests, Subacute