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[Danger signals and inflammasomes in autoinflammatory and autoimmune diseases].

Abstract
Cytoplasmic inflammasomes are formed through activation of pattern recognition receptors (PRR) of the innate immune system. Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ß-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. These inflammasomes govern the induction of proinflammatory cytokines such as IL-1ß, IL-18 and IL-33. PRR and inflammasome dysfunctions may underly immunoinflammatory diseases such as gout and other arthritides, type 1 diabetes and arteriosclerosis.
AuthorsKlaus Bendtzen
JournalUgeskrift for laeger (Ugeskr Laeger) Vol. 173 Issue 38 Pg. 2340-3 (Sep 19 2011) ISSN: 1603-6824 [Electronic] Denmark
Vernacular TitleDanger-signaler og inflammasomer ved autoinflammatoriske og autoimmune sygdomme.
PMID21936977 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cytokines
  • Inflammasomes
  • Nod Signaling Adaptor Proteins
  • Receptors, Pattern Recognition
  • Receptors, Tumor Necrosis Factor
  • Toll-Like Receptors
Topics
  • Arteriosclerosis (immunology)
  • Arthritis (immunology)
  • Autoimmune Diseases (immunology)
  • Cytokines (immunology)
  • Diabetes Mellitus, Type 1 (immunology)
  • Hereditary Autoinflammatory Diseases (immunology)
  • Humans
  • Immunity, Innate (immunology)
  • Inflammasomes (immunology)
  • Inflammation (immunology)
  • Nod Signaling Adaptor Proteins (immunology)
  • Receptors, Pattern Recognition (immunology)
  • Receptors, Tumor Necrosis Factor (immunology)
  • Toll-Like Receptors (immunology)

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