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Expression of odontogenic ameloblast-associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations.

Abstract
Screening for expression of amelogenesis-related proteins represents a powerful molecular approach to characterize odontogenic tumors and investigate their pathogenesis. In this study, we have examined the presence and distribution of odontogenic ameloblast-associated protein (ODAM), amelotin (AMTN), ameloblastin (AMBN), and amelogenin (AMEL) by immunohistochemistry in samples of adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), developing odontoma, ameloblastoma, calcifying cystic odontogenic tumor (CCOT), ameloblastic fibroma (AF), myxoma, odontogenic fibroma (OF), and reduced enamel epithelia (REE). Positive results were obtained in those tumors with epithelial component, except for AF, OF, and ameloblastoma. ODAM was found around mineralized structures (dystrophic calcifications) and CEOT's amyloid, whereas AMTN stained the eosinophilic material of AOTs. The CCOT transitory cells to ghost cells were strongly positive with all proteins except AMEL, and the REE as well as odontomas showed immunoexpression for ODAM, AMTN, AMBN, and AMEL similar to those found in normal rat tooth germs. Based on these results, some histopathogenetic theories were formulated.
AuthorsMarcelo Macedo Crivelini, Renata Callestini Felipini, Glauco Issamu Miyahara, Suzana Cantanhede Orsini Machado de Sousa
JournalJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 41 Issue 3 Pg. 272-80 (Mar 2012) ISSN: 1600-0714 [Electronic] Denmark
PMID21936873 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 John Wiley & Sons A/S.
Chemical References
  • Ambn protein, rat
  • Amelogenin
  • Amtn protein, rat
  • Amyloid
  • Calcium-Binding Proteins
  • Dental Enamel Proteins
  • ODAM protein, rat
Topics
  • Ameloblastoma (pathology)
  • Ameloblasts (pathology)
  • Amelogenin (analysis)
  • Amyloid (analysis)
  • Animals
  • Basement Membrane (pathology)
  • Calcinosis (pathology)
  • Calcium-Binding Proteins (analysis)
  • Dental Enamel (pathology)
  • Dental Enamel Proteins (analysis)
  • Dental Sac (pathology)
  • Epithelial Cells (pathology)
  • Epithelium (pathology)
  • Hyalin (chemistry)
  • Immunohistochemistry
  • Odontogenic Cyst, Calcifying (pathology)
  • Odontogenic Tumors (etiology, pathology)
  • Odontoma (pathology)
  • Rats
  • Tooth Germ (pathology)

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