Randomized trial of doxycycline versus josamycin for Mediterranean spotted fever.

Abstract	We undertook a randomized clinical trial comparing therapeutic efficacy of the 1-day doxycycline regimen with the 5-day josamycin regimen for Mediterranean spotted fever. All 59 patients recovered uneventfully, and results did not significantly differ between the two schedules. One-day doxycycline therapy is an effective, easy, and inexpensive treatment. Josamycin is a useful therapeutic alternative that may be particularly convenient for pregnant women and patients with a history of allergy to tetracyclines.
Authors	F Bella, B Font, S Uriz, T Muñoz, E Espejo, J Traveria, J A Serrano, F Segura
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 34 Issue 5 Pg. 937-8 (May 1990) ISSN: 0066-4804 [Print] United States
PMID	2193627 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Josamycin Doxycycline
Topics	Adolescent Adult Aged Child Child, Preschool Doxycycline (therapeutic use) Female Humans Josamycin (therapeutic use) Male Middle Aged Randomized Controlled Trials as Topic Rickettsia Infections (drug therapy)

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