[Collagenase Clostridum histolyticum in the management of Dupuytren's contracture].

Abstract

Dupuytren's contracture is a fibroproliferate disease of the palmar aponeurosis with a formation of nodules and cords. Surgical treatment is the gold standard for Dupuytren's contracture at the moment. A short while ago Collagenase clostridium histolyticum was licensed as a non-surgical method to treat Dupuytren's contracture. Collagenase clostridium histolyticum is injected directly into the Dupuytren's cord and after 24 h the contracture is distended by manual rupturing. Collagenase clostridium histolyticum causes a depletion of collagen, however neurovascular structures are spared. 2 clinical phase III studies showed that contractures could be effectively reduced when using Collagenase clostridium histolyticum. However, there are no long-term results regarding effectiveness and side effects, or comparative studies using surgical methods. This paper presents a review of Collagenase clostridium histolyticum and its role in the management of Dupuytren's contracture. Indication, technical procedure, treatment results and complications are described.

• Authors: L A Holzer, G Holzer
• Journal: Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... (Handchir Mikrochir Plast Chir) Vol. 43 Issue 5 Pg. 269-74 (Oct 2011) ISSN: 1439-3980 [Electronic] Germany
• Vernacular Title: Kollagenase Clostridium histolyticum im Management der Dupuytrenschen Kontraktur.
• PMID: 21935843 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Microbial Collagenase

Topics

• Animals
• Clinical Trials, Phase III as Topic
• Clostridium histolyticum (enzymology)
• Dupuytren Contracture (blood, drug therapy)
• Follow-Up Studies
• Humans
• Injections
• Male
• Metabolic Clearance Rate (physiology)
• Microbial Collagenase (adverse effects, pharmacokinetics, therapeutic use)
• Penile Induration (blood, drug therapy)
• Rats
• Recurrence
• Retreatment