The role of vitamin E in immune response and disease resistance.

Vitamin E supplementation enhances humoral and cell-mediated immunity, and augments the efficiency of phagocytosis in laboratory animals, farm animals, and humans. In its disease protection effect vitamin E interacts with other antioxidant nutrients and with other nutrients in the diet. Other antioxidant nutrients, such as vitamin A and beta carotene, also enhance disease resistance. Beta carotene is effective in combination with vitamin E. The optimal dose of vitamin E for maximum protection depends on many factors; thus it has to be established case by case. The delivery system of vitamin E greatly influences its effectiveness. A targeted delivery to localized immunocompetent cells in adjuvant formulations is far more effective than a general dispersed delivery in a diet. Vitamin E adjuvants provided greater immunoprotection against enterotoxemia and epididymitis in sheep than conventional vaccines.
AuthorsR P Tengerdy
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 587 Pg. 24-33 ( 1990) ISSN: 0077-8923 [Print] UNITED STATES
PMID2193574 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Adjuvants, Immunologic
  • beta Carotene
  • Vitamin A
  • Vitamin E
  • Carotenoids
  • Adjuvants, Immunologic (pharmacology)
  • Animals
  • Carotenoids (pharmacology)
  • Food, Fortified
  • Humans
  • Immunity (drug effects)
  • Phagocytosis (drug effects)
  • Vitamin A (pharmacology)
  • Vitamin E (administration & dosage, pharmacology)
  • beta Carotene

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