Abstract | BACKGROUND: METHODS: Participants of the 3rd National Health and Nutrition Examination Survey > 20 years of age and free of hypertension (n = 9,215, 53.5% women) and clinical cardiovascular disease were examined. Serum vitamin D levels were analyzed as quartiles. Prehypertension (n = 3,712) was defined as systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg. RESULTS: Lower serum vitamin D levels were found to be associated with prehypertension independent of potential confounders including body mass index (BMI), serum cholesterol, C-reactive protein and estimated glomerular filtration rate. Compared to the highest quartile of serum vitamin D (referent), the odds ratio (95% confidence interval) of prehypertension associated with the lowest quartile was 1.48 (1.16-1.90; p trend < 0.0001). This association persisted in subgroup analyses by gender, race-ethnicity and BMI. CONCLUSION:
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Authors | Charumathi Sabanayagam, Anoop Shankar, Shanmugasundaram Somasundaram |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 35
Issue 2
Pg. 106-13
( 2012)
ISSN: 1423-0143 [Electronic] Switzerland |
PMID | 21934326
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Vitamin D
- C-Reactive Protein
- Cholesterol
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Topics |
- Adult
- Blood Pressure
(physiology)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Cholesterol
(blood)
- Female
- Glomerular Filtration Rate
(physiology)
- Humans
- Male
- Nutrition Surveys
- Prehypertension
(blood, epidemiology)
- Prevalence
- Risk Factors
- Smoking
(epidemiology)
- Vitamin D
(blood)
- Vitamin D Deficiency
(blood, epidemiology)
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