Abstract |
A novel series of indolin-2-one derivatives containing the 4-thiazolidinone moiety (5a-5p) was synthesized and the cytotoxicity of these derivatives was evaluated in vitro against three human cancer cell lines (HT-29, H460 and MDA-MB-231) by standard MTT assay. Some prepared compounds exhibited significant cytotoxicity against different human cancer cell lines. Several potent compounds were further evaluated against one normal cell line (WI-38). In particular, the promising compound 5h showed remarkable cytotoxicity and selectivity against the HT-29 and H460 cancer cell lines (IC(50) = 0.016 µmol/L, 0.0037 µmol/L, respectively).
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Authors | Shuobing Wang, Yanfang Zhao, Wufu Zhu, Ying Liu, Kaixing Guo, Ping Gong |
Journal | Archiv der Pharmazie
(Arch Pharm (Weinheim))
Vol. 345
Issue 1
Pg. 73-80
(Jan 2012)
ISSN: 1521-4184 [Electronic] Germany |
PMID | 21932254
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Antineoplastic Agents
- Indoles
- Thiazoles
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Cell Culture Techniques
- Cell Survival
(drug effects)
- Chemistry Techniques, Synthetic
- Drug Design
- HT29 Cells
- Humans
- Indoles
(chemical synthesis, chemistry, pharmacology)
- Inhibitory Concentration 50
- Molecular Structure
- Stereoisomerism
- Structure-Activity Relationship
- Thiazoles
(chemistry)
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